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KMID : 0043320110340030419
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Archives of Pharmacal Research
2011 Volume.34 No. 3 p.419 ~ p.423
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Inhibitory activity of Plantago major L. on angiotensin I-converting enzyme
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Nhiem Nguyen Xuan
Tai Bui Huu
Kiem Phan Van
Minh Chau Van
Cuong Nguyen Xuan
Tung Nguyen Huu
Thu Vu Kim
Trung Trinh Nam
Anh Hoang Le Tuan
Jo Sung-Hoon
Jang Hae-Dong
Kwon Young-In
Kim Young-Ho
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Abstract
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Eight compounds were isolated from methanol extract of Plantago major L. leaves and investigated for their ability to inhibit angiotensin I-converting enzyme activity. Among them, compound 1 showed the most potent inhibition with rate of 28.06 ± 0.21% at a concentration of 100 μM. Compounds 2 and 8 exhibited weak activities. These results suggest that compound 1 might contribute to the ability of P. major to inhibit the activity of angiotensin I- converting enzyme.
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KEYWORD
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Angiotensin I-converting enzyme, Antihypertensive effect, Plantago major
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